publication . Article . 2018

EFFICACY AND SAFETY OF ANTIEPILEPTIC DRUGS DURING PREGNANCY: PHARMACOGENETIC ASPECTS

E. A. Sоkоvа; V. V. Arkhipov; R. A. Chilova; O. A. Demidova; G. F. Proklova; T. V. Pikuza;
Open Access
  • Published: 22 Jun 2018 Journal: The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products, volume 8, pages 72-76 (issn: 1991-2919, Copyright policy)
  • Publisher: SCEEMP
Abstract
This paper summarises scientific literature on pharmacotherapy of epilepsy in pregnant women from the perspective of clinical pharmacology. It analyses general principles of antiepileptic therapy in pregnant women. It was demonstrated that the optimal conditions for treating epilepsy during pregnancy involve the use of the minimum dose of an anticonvulsant. The article describes specific pharmacokinetic parameters of antiepileptic drugs (valproic acid, carbamazepine, lamotrigine, phenytoin, phenobarbital) that require adjustment of the dose regimen based on therapeutic drug monitoring. It was demonstrated that carriership of «slow» allelic variants of CYP2C9 is ...
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free text keywords: pregnancy, antiepileptic drugs, pharmacokinetics, pharmacogenetics, safety, efficacy, drug transporters, therapeutic drug monitoring, Medicine (General), R5-920, Lamotrigine, medicine.drug, medicine, Therapeutic drug monitoring, medicine.diagnostic_test, Anticonvulsant, medicine.medical_treatment, Topiramate, Valproic Acid, Primidone, Carbamazepine, Oxcarbazepine, Pharmacology, business.industry, business
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