publication . Article . 2018

ANALGESIC POTENTIAL OF PURINE RECEPTOR AGONISTS AND B VITAMINS IN THE TREATMENT OF DIABETIC POLYNEUROPATHY

O. A. Demidova; E. V. Shikh;
Open Access
  • Published: 01 Mar 2018 Journal: The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products, volume 8, pages 17-22 (issn: 1991-2919, Copyright policy)
  • Publisher: SCEEMP
Abstract
The efficacy and safety of purine receptor agonists in patients with chronic pain have been analysed. The data on the clinical application of purine analgesia in the management of pain syndrome are reviewed. The use of purine analgesia for the treatment of patients with chronic neuropathic pain is scientifically justified. The central mechanisms of purine receptor agonists and their analgesic activity are described in detail. It has been shown that purine receptor agonists have a strong analgesic effect and a narrow range of side effects, and they effectively relieve neuropathic pain by influencing the purinergic regulatory mechanism. The mechanisms of the analg...
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free text keywords: purine receptor agonists, neuropathic pain, analgesic effect, diabetic polyneuropathy, b vitamins, Medicine (General), R5-920, Purinergic receptor, Analgesic, Chronic pain, medicine.disease, medicine, Neuropathic pain, Pharmacology, Pharmacotherapy, B vitamins, business.industry, business, Purine, chemistry.chemical_compound, chemistry, Receptor
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