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EFSA Journal
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Evaluation of confirmatory data following the Article 12 MRL review for dimethenamid‐P

Authors: European Food Safety Authority (EFSA); Maria Anastassiadou; Alba Brancato; Luis Carrasco Cabrera; Lucien Ferreira; Luna Greco; Samira Jarrah; +14 Authors

Evaluation of confirmatory data following the Article 12 MRL review for dimethenamid‐P

Abstract

The applicant BASF SE submitted a request to the competent national authority in Germany to evaluate the confirmatory data that were identified for dimethenamid-P in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available. The data gap refers to the submission of a plant metabolism study investigating the fate of dimethenamid-P following foliar treatment with a short preharvest interval (PHI) in a leafy or bulb vegetable crop. The confirmatory data requirement is considered sufficiently addressed according to the conclusions of the peer review, which, based on available metabolism studies, proposed to modify the existing enforcement and risk assessment residue definitions in all plant commodities, by including additional dimethenamid-P metabolites ((2RS)-3-(2-{(2,4-dimethylthiophen-3-yl)[(2S)-1-methoxypropan-2-yl]amino}-2-oxoethanesulfinyl)-2-hydroxypropanoic acid (M30) and (2RS)-3-[(2-{(2,4-dimethylthiophen-3-yl)[(2S)-1-methoxypropan-2-yl]amino}-2-oxoethyl)sulfanyl]-2-hydroxypropanoic acid (M26). The residue data of metabolites M26 and M30 are currently not available for all authorised uses assessed in the MRL review. Should risk managers decide amending residue definitions, the existing EU MRLs would need to be revised accordingly. The consumer exposure as calculated by the MRL review was updated in two scenarios, using the existing and the new toxicological reference values as derived by the peer review. For the crops under consideration (spring onions, lettuce, escarole and herbs), indicative conversion factors were applied to account for possible metabolite burden. No consumer intake concerns were identified.

Keywords

confirmatory data, Nutrition. Foods and food supply, Chemical technology, MRL review, risk assessment, TX341-641, TP1-1185, dimethenamid‐P, pesticide, Reasoned Opinion

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
gold