publication . Other literature type . Article . 2020

RET proto-oncogene mutations in the Slovenian population of patients with medullary thyroid cancer

Sara Milićević; Damijan Bergant; Tina Žagar; Barbara Perić;
Open Access English
  • Published: 01 May 2020
  • Publisher: Onkologija : a medical-scientific journal
  • Country: Slovenia
Abstract
Background. Medullary thyroid cancer (MTC) is a rare, endocrine tumour that occurs as part of hereditary cancer syndrome in approximately 25% of cases and develops as a sporadic form in 75%. The aim of the study was to evaluate the frequency and type of RET mutation occurrence in the Slovenian population between 1995 and 2015. Methods. A retrospective analysis of the National Cancer Registry of the Republic of Slovenia and the Registry of Patients with MTC of the Institute of Oncology in Ljubljana between 1995 and 2015 was made. The data of 143 patients with confirmed MTC and 43 healthy relatives referred to genetic counselling and testing was analyzed. Genomic ...
Subjects
Medical Subject Headings: endocrine system diseases
free text keywords: medularni karcinom ščitnice, multipla endokrina neoplazija 2, genetsko svetovanje, incidenca, medullary thyroid carcinoma, multiple endocrine neoplasia 2, genetic counselling and testing, total thyroidectomy, crude incidence rate, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, udc:616.4
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