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Disbiose e desenvolvimento de pré-eclâmpsia e eclampsia

Authors: Carolina Soares Cardoso; Roberta Furtado Stivanin Rachid Novais;

Disbiose e desenvolvimento de pré-eclâmpsia e eclampsia

Abstract

Objetivo: Analisar a relação da disbiose dos microbiomas intestinal, vaginal e oral com o desenvolvimento de pré-eclâmpsia e eclâmpsia. Métodos: Esta revisão integrativa envolveu a busca de estudos nas bases de dados National Library of Medicine, Literatura Latino-Americana e do Caribe em Ciências da Saúde e Cochrane Library, onde foram encontrados quinze artigos acerca do tema, após selecionados os critérios de inclusão e exclusão. Resultados: Todos os artigos analisados são do tipo ensaio clínico. Dentre eles, treze avaliam o microbioma intestinal, um vaginal e um avalia concomitante os microbiomas intestinal, vaginal e oral. Considerações finais: Existem bactérias com ação protetora e outras com ação deletéria envolvidas no mecanismo da fisiopatologia da pré-eclâmpsia (PE). A barreira intestinal realizada pelas bactérias protetoras que produzem ácidos graxos de cadeia curta possui efeitos anti-inflamatórios e antioxidantes que podem prevenir a inflamação placentária e consequentemente o desenvolvimento da PE, e é por meio da investigação dos metabólitos produzidos por essas bactérias que será possível focar em alvos para prevenção e tratamento da doença.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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