Abstract This paper will discuss the comparison between the three leading Syngas manufacturing technologies; Partial Oxidation (POX), Autothermal Reforming (ATR) and the Steam Methane Reformer (SMR) technology. Also, this paper will discuss the development of the Catalytic Partial Oxidation COPox syngas technology. The discussion will focus on illustrating the general syngas chemistry of each technology and where the COPox process fits into the spectrum of syngas technologies. It will also discuss the application of the first two technologies in commercial plants and some of the critical operating parameters that can influence the performance and the efficiency of syngas production such as, feed gas composition, operating temperate and pressure. Syngas can use in the Fischer-Tropsch and methanol process, as fuel, or as an intermediate for chemical production. Syngas treatment and removal of sulfur, NH3, soot and HCN containing compounds is essential to the final application of the gas. This paper wills discuss the effect of the impurities in the syngas.