Tandem Lesions and Other Products in X-Irradiated DNA Oligomers

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1998Publisher:JSTORJournal:Radiation Research, volume 149, page 433 (issn: 0033-7587,

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Authors: H C, Box; E E, Budzinski; J B, Dawidzik; J C, Wallace; H, Iijima;

doi: 10.2307/3579782

pmid: 9588353

Tandem Lesions and Other Products in X-Irradiated DNA Oligomers

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Abstract

Free radicals interact with DNA bases to produce secondary radicals. The secondary radicals are reactive species and tend to interact with neighboring bases, resulting in DNA lesions with two adjacent modified bases. In this study the DNA oligomers d(CpApTpG) and d(CpGpTpA) were exposed to free radicals generated in anoxic aqueous solution by X irradiation. Four new lesions were identified in which adjacent guanine and pyrimidine bases are covalently bonded. One of the tandem lesions formed in d(CpGpTpA) has the C5 carbon atom of cytosine covalently bonded to the C8 carbon atom of guanine. Interestingly, the same bond is formed between the terminal bases in d(CpApTpG), resulting in a cyclized molecule.

Related Organizations

Roswell Park Cancer Institute
United States

Keywords

Biopolymers, Guanine, Magnetic Resonance Spectroscopy, Free Radicals, Purines, Nucleic Acid Conformation, DNA, Thymine, DNA Damage

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