
doi: 10.2307/2533002
pmid: 7548688
This report concerns likelihood ratio tests in a heterogeneous model for linkage, where the recombination fraction has a binomial mixture distribution with an unknown proportion of unlinked families. We consider families of unequal sizes with known or unknown phase data. In both cases, the limit distributions of the linkage test statistics are a mixture of a mass at ) and of a X2/1 distribution in equal proportions and homogeneity test statistics tend to the supremum of Gaussian processes. The critical values of the homogeneity tests are simulated, and the power functions of the linkage and homogeneity tests are compared in a simulation study.
critical values, Biometry, limit distributions, Genetic Linkage, [SDV]Life Sciences [q-bio], heterogeneous model, Normal Distribution, Gaussian processes, Applications of statistics to biology and medical sciences; meta analysis, Humans, Family, Probability, tables, Recombination, Genetic, binomial mixture distribution, Models, Statistical, Models, Genetic, Asymptotic distribution theory in statistics, homogeneity tests, likelihood ratio tests, power functions, simulation study, [SDV] Life Sciences [q-bio], Genetics and epigenetics, linkage
critical values, Biometry, limit distributions, Genetic Linkage, [SDV]Life Sciences [q-bio], heterogeneous model, Normal Distribution, Gaussian processes, Applications of statistics to biology and medical sciences; meta analysis, Humans, Family, Probability, tables, Recombination, Genetic, binomial mixture distribution, Models, Statistical, Models, Genetic, Asymptotic distribution theory in statistics, homogeneity tests, likelihood ratio tests, power functions, simulation study, [SDV] Life Sciences [q-bio], Genetics and epigenetics, linkage
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 27 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
