Studies on Interferon Induction by Infectious Bursal Disease Virus (IBDV). I. Interferon Production in Chicken Embryo Cell Cultures Infected with IBDV

SUMMARY Two isolants of infectious bursal disease virus (IBDV) were found to induce interferon production in chicken embryo fibroblast (CEF) cell cultures. Both isolants were similar in one-step multiplication cycles and interferon-inducing properties. Interferon production was closely related to virus multiplication. The production of new virus preceded the synthesis of interferon by about 2 to 8 hours, and interferon titers reached a maximum by the 18th to 24th hour postinoculation (PI). The virus inhibitor had physicochemical and biological properties characteristic of virus-induced interferons.

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