Regionalization is a contemporary conception of a development within a society. We are interested in cooperation at regions whose area is intersected by the national border. One of those borders is the Drina River that in different periods had changeable role of connecting or separating. In this way we want to stress the necessity of making a stronger, functional connection and developing of overall process of integration in the Podrinje region, on a land between the two republics-Serbia and the Republic of Srpska, because we think that this area has the most reasons for that, but so far it has been done very little. The first attempts to form Euroregions in Lower Podrinje region have already started, but it lacks many activities for this area to receive a cross-border role that it deserves.