A 28-year-old autonomous male presented with asthenia and a painless lesion in the upper labial frenulum region, with progressive growth for 3 months. In the last 5 days he also developed high fever. He revealed na unprotected heterosexual anal contact a year ago. No relevant past medical history or usual medication was found. Physical examination revealed a temperature of 40.5°C, a sessile swelling of about 2cm in the superior alveolar arch and ecchymotic infiltration of the remaining alveolar arch, and bilaterally palpable cervical adenomegaly of area II, with reactive features. Labs showed anemia, lymphopenia, thrombocytopenia, positive HIV test, CD4+ count of 11, viral load 799363 units. A diagnosis of HIV disease in AIDS stage was made. Lesion biopsy confirmed Kaposi's Sarcoma. He started antiretroviral therapy with Darunavir, Cobicistat, Tenofovir Alafenamide and Emtricitabine, as well as doxorubicin, with an undetectable viral load and with only a residual lesion 6 months later.