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Publication . Article . 2011

Allopurinol pharmacogenetics: assessment of potential clinical usefulness

Issam Zineh; Padmaja Mummaneni; Jenna Lyndly; Shashi Amur; Lois La Grenade; Stephen H Chang; Hobart Rogers; +1 Authors
Open Access
Published: 01 Dec 2011
Publisher: Zenodo
Abstract
Use of pharmacogenetics to inform treatment decisions remains a priority for clinicians, patients and public health agencies. We previously developed a framework for systematically assessing whether pharmacogenetic test information would likely bring value to clinical decision-making and enjoy practical uptake. We applied this tool to allopurinol to determine potential usefulness of HLA genetic information in assessing risk for allopurinol-induced severe cutaneous adverse reactions. We quantified allopurinol use data and the magnitude of adverse event signals using US FDA databases, reviewed reported cases of allopurinol-associated severe cutaneous adverse reactions to assess whether clinical subtypes of patients could be identified, performed pooled analyses of associations between HLA variation and allopurinol-induced severe cutaneous adverse reactions and described considerations in clinical implementation of allopurinol pharmacogenetics.
Subjects by Vocabulary

Medical Subject Headings: musculoskeletal diseases

Microsoft Academic Graph classification: Allopurinol medicine.drug medicine Pharmacology Intensive care medicine medicine.medical_specialty MEDLINE business.industry business Adverse effect Pharmacogenetics Risk assessment Treatment decision making Public health Pharmacogenetic Test

Subjects

Pharmacology, Genetics, Molecular Medicine

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