siRNA-Based Nanomedicine

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type , Review 01 Jun 2013 Singapore English Publisher:Informa UK LimitedJournal:Nanomedicine, volume 8, pages 859-862 (issn: 1743-5889, eissn: 1748-6963,

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Authors: Zhao, J.; Mi, Y.; Feng, S.-S.;

doi: 10.2217/nnm.13.73

pmid: 23730692

siRNA-Based Nanomedicine

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Abstract

By nature, cancer cells are the toughest cells against any treatment. The various available therapies would be much more effective at much lower dose if siRNA against the therapeutic resistance could be identified and successfully codelivered by nanocarriers such as polymer conjugation, micelles, liposomes, solid lipid nanoparticles, nanohydrogels and dendrimers. Cancer is a significant health problem world wide. The death rate of cancer among the various diseases was 23.3% in the USA in 2010 and 30.0% in Singapore in 2011. Patients with cancers that are detected at later stages have a lower 5 - year relative survival (23.3% for breast cancer, 11.7% for colon cancer and 3.6% for

Country

Singapore

Related Organizations

National University of Singapore
Singapore
National University of Singapore Libraries
Singapore

Keywords

RNAi therapeutics, biodegradable polymer, chemotherapy, Nanostructures, nanoimmunotherapy, thermotherapy, Drug Delivery Systems, Nanomedicine, multidrug resistance, Neoplasms, Animals, Humans, RNA, Small Interfering

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