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Future Microbiology

Article . 2024 . Peer-reviewed

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Future Microbiology

Article . 2024

Data sources: Europe PubMed Central

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Rise and fall of Caspofungin: the current status of Caspofungin as a treatment for Cryptococcus neoformans infection

Name: Rise and fall of Caspofungin: the current status of Caspofungin as a treatment for Cryptococcus neoformans infection
Keywords: Echinocandins, Lipopeptides, Antifungal Agents, Caspofungin, Drug Resistance, Fungal, Cryptococcus neoformans, Humans, Animals, Cryptococcosis, Microbial Sensitivity Tests

descriptionPublicationkeyboard_double_arrow_right Article 18 Mar 2024 English Publisher:Informa UK LimitedJournal:Future Microbiology, volume 19, pages 621-630 (issn: 1746-0913, eissn: 1746-0921,

Authors: Tawanny KB Aguiar; Ana CM Costa; Nilton AS Neto; Daiane MS Brito; Cleverson DT Freitas; João MM Neto; Felipe P Mesquita; +1 Authors

doi: 10.2217/fmb-2023-0236

pmid: 38497911

pmc: PMC11229582

Rise and fall of Caspofungin: the current status of Caspofungin as a treatment for Cryptococcus neoformans infection

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Abstract

Antifungal infections are becoming a major concern to human health due to antimicrobial resistance. Echinocandins have been promising agents against resistant fungal infections, primarily caspofungin, which has a more effective mechanism of action than azoles and polyenes. However, fungi such as Cryptococcus neoformans appear to be inheritably resistant to these drugs, which is concerning due to the high clinical importance of C. neoformans. In this review, we review the history of C. neoformans and the treatments used to treat antifungals over the years, focusing on caspofungin, while highlighting the C. neoformans problem and possible explanations for its inherent resistance.

Related Organizations

University of Brasília
Brazil
Universidade Federal do Ceará
Brazil

Keywords

Echinocandins, Lipopeptides, Antifungal Agents, Caspofungin, Drug Resistance, Fungal, Cryptococcus neoformans, Humans, Animals, Cryptococcosis, Microbial Sensitivity Tests

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