publication . Article . Other literature type . 2014

Molecular characteristics of pediatric high-grade gliomas

Chamdine, Omar; Gajjar, Amar;
Open Access
  • Published: 01 Nov 2014
  • Publisher: Future Medicine Ltd
Abstract
SUMMARY High-grade gliomas (HGGs) are extremely lethal tumors. Survival has not changed significantly in the past decades. The only known prognostic factors in pediatric HGGs (pHGGs) are extent of resection and histologic grade. Treatment has historically been based on adult trials because of the rarity of pHGGs and the lack of genomic tools to explore their unique molecular characteristics. The recent advances in molecular biological data helped divide these tumors into distinct subgroups. In this review, the authors focus on major molecular targets of alterations in pHGGs: histone H3.3, telomeres, PDGFRA, IDH, BRAF V600E, ACVR1 and NTRK and briefly highlight...
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free text keywords: General Medicine, Article, ACVR1, Cancer research, Glioma, medicine.disease, medicine, Extent of resection, Neoplasm Grading, business.industry, business, Histologic grade, PDGFRA, BRAF V600E, Epigenetics
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Other literature type . 2014
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