publication . Part of book or chapter of book . Article . 2006

Glucocorticoid-Induced Osteoporosis

Luiz Henrique de Gregório; Paulo Gustavo Sampaio Lacativa; Ana Cláudia Caucegli Melazzi; Luis Augusto Tavares Russo;
Open Access
  • Published: 01 Aug 2006
  • Publisher: Elsevier
Abstract
Glucocorticoid-induced osteoporosis is the most frequent cause of secondary osteoporosis. Glucocorticoids cause a rapid bone loss in the first few months of use, but the most important effect of the drug is suppression of bone formation. The administration of oral glucocorticoid is associated with an increased risk of fractures at the spine and hip. The risk is related to the dose, but even small doses can increase the risk. Patients on glucocorticoid therapy lose more trabecular than cortical bone and the fractures are more frequent at the spine than at the hip. Calcium, vitamin D and activated forms of vitamin D can prevent bone loss and antiresorptive agents ...
Subjects
free text keywords: Epidemiology, Fractures/risk factors, Glucocorticoid/adverse reactions, Osteoporosis, Review, General Medicine, Endocrinology, Diabetes and Metabolism, Fraturas, Fatores de risco, Glicocorticóides, Reações adversas, Osteoporose, Osteoporosis, medicine.disease, medicine, Surgery, medicine.medical_specialty, Fracture risk, Glucocorticoid, medicine.drug, Treatment options, Intensive care medicine, Guideline, Calcitonin, business.industry, business, MEDLINE, Pathophysiology, Glucocorticoid therapy, Effective management, Low dose, In patient, Internal medicine, Epidemiology, Endocrinology, Drug, media_common.quotation_subject, media_common, Vitamin D and neurology, Calcium, chemistry.chemical_element, chemistry, Cortical bone, medicine.anatomical_structure, Secondary osteoporosis, lcsh:Diseases of the musculoskeletal system, lcsh:RC925-935
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