The sedentary life style is carried out in labor and domestic activities; the use of means of transport has caused the reduction of the physical activity. The physical inactivity reduces the health benefits. The main goal of this study is to create an Index of Sedentary lifestyle (ISLM) for Mexican people aged from 20 to 69, in this way, it allows to predict its main causes taking as reference a factor analysis. The source of information is taken from National Health and Nutrition Examination (NHANES) 2012. For this analysis was considered the vigorous activity[1], the time spent sitting on a means of transport, the time spent watching TV and doing physical activity. As a conclusion, it was determined that the state of Nuevo Leon obtained a higher ISLM that stands above the rest of the entities of the country. [1]Vigorous Physical Activity ≥150 min/week, and/or moderate physical activity ≥300 min/week (NHANES, 2012).