The French Departments of Guadeloupe and Martinique are particularly sensitive to the problem of invasive species. This problem is the responsibility of the Services and other organizations in charge of animal and plant health. These agencies have established concerted information activities and regional co-operation aimed at preventing the introduction and the control of invasive species, which could have important economic impacts on agricultural production and the ecosystems of these Departments. We report the strategy of regional co-operation and progress pertaining to some potential invasive species or species undergoing mutation, and the prospects for controlling them in the event of their introduction.