publication . Article . Conference object . 2008

Benzodiazepine Metabolism: An Analytical Perspective

Roberto Mandrioli; Laura Mercolini; Maria Augusta Raggi;
Open Access
  • Published: 01 Oct 2008
  • Country: Italy
Benzodiazepines are currently among the most frequently prescribed drugs all over the world. They act as anxiolytics, sedatives, hypnotics, amnesics, antiepileptics and muscle relaxants. Despite their common chemical scaffold, these drugs differ in their pharmacokinetic and metabolic properties. In particular, they are biotransformed by different cytochrome P450 isoforms and also by different UDP-glucuronosyltransferase subtypes. The most important studies on the metabolic characteristics of several 1,4-benzodiazepines, carried out from 1998 onwards, are reported and briefly discussed in this review. Moreover, the analytical methods related to these studies are ...
Persistent Identifiers
free text keywords: BENZODIAZEPINES, TDM, ANALYSIS, BIOLOGICAL FLUIDS, METABOLISM, ANALYTICAL METHODS, CYTOCHROME P450, UDP-GLUCURONOSYLTRANSFERASE, SAMPLE PRE-TREATMENT, Clinical Biochemistry, Pharmacology, Brotizolam, medicine.drug, medicine, Oxazepam, Chemistry, Etizolam, Triazolam, Alprazolam, Bromazepam, Lorazepam, Pharmacology, Benzodiazepine, medicine.drug_class
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