Aim: The aim of the study is to study the elemental composition of the leafy shoots, rhizomes, and roots of D. fruticosa varieties cultivated in Ukraine. Background: Dasiphora fruticosa (L.) Rybd. (Rosaceae) is a species native to Middle Asia and the Far East. More than 130 D. fruticosa varieties are known; plants have a significant raw material base and are promising objects for phytochemical research. Data only on the elemental composition of the aboveground parts of the wild-grown D. fruticosa is present. No information on the elemental composition of the raw materials of cultivated D. fruticosa varieties is available. Objective: A comprehensive analysis of the elemental composition of Dasiphora fruticosa varieties and identification of the features of macro- and microelements translocation. Methods: For all D. fruticosa varieties, raw materials were taken from two plants with five replicates per plant. The elemental composition was studied by atomic absorption spectroscopy. Using corresponding formulas, translocation factors of elements were determined, and a hygienic full-value of the raw materials was established. Results: In the studied raw materials, fourteen elements were identified and quantified. The translocation factors of potentially toxic elements Mo, Cu, Ni, and Sr indicate a capture of these elements in the root system and a presence of the barrier mechanisms preventing their accumulation in D. fruticosa varieties shoots. Conclusion: The results obtained show the presence of the barrier mechanisms preventing the accumulation of potentially toxic elements in aboveground parts of D. fruticosa varieties and justify a need for the study of those mechanisms.