publication . Article . 2006

Clinical Pharmacokinetics and Pharmacodynamics of Buspirone, an Anxiolytic Drug

Iftekhar Mahmood; Chandra Sahajwalla;
Open Access
  • Published: 19 Jan 2006 Journal: Clinical Pharmacokinetics, volume 36, pages 277-287 (issn: 0312-5963, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Buspirone is an anxiolytic drug given at a dosage of 15 mg/day. The mechanism of action of the drug is not well characterised, but it may exert its effect by acting on the dopaminergic system in the central nervous system or by binding to serotonin (5-hydroxytryptamine) receptors. Following a oral dose of buspirone 20mg, the drug is rapidly absorbed. The mean peak plasma concentration (Cmax) is approximately 2.5 μg/L, and the time to reach the peak is under 1 hour. The absolute bioavailability of buspirone is approximately 4%.Buspirone is extensively metabolised. One of the major metabolites of buspirone is 1-pyrimidinylpiperazine (1-PP), which may contribute to...
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free text keywords: Pharmacology (medical), Pharmacology, Pharmacology, Serotonin, Cmax, Medicine, business.industry, business, Pharmacokinetics, Buspirone, medicine.drug, Mechanism of action, medicine.symptom, Oral administration, Drug, media_common.quotation_subject, media_common, Drug interaction
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