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Publication . Article . 2017

ADDITION TO THE QUASI-BIOLOGICAL MODEL OF RADIOGENIC CANCER MORBIDITY

A. Т. Gubin; V. A. Sakovich;
Open Access
English
Published: 01 Jan 2017 Journal: Radiacionnaâ Gigiena, volume 10, issue 4, pages 53-58
Publisher: Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev
Abstract
Object: The purpose was to refine the quasi-biological model of the incidence of radiogenic solid cancer (published by the authors earlier in the journal “Radiation hygiene”) to ensure better consistency with the Japanese cohort data and with the ICRP model in part of the description of the effect of age at exposure. Results: Initial presuppositions of a mathematical model was supplemented by the assumption that stem cells, received the “pre-cancerous” defect of DNA, with a higher probability compared to the intact cells follow the path of reproduction but not of differentiation. Structure of the refined model and its properties did not change, but one parameter was added. Analysis of the base mathematical relations of the supplemented model showed that there was no contradiction between the models of radiogenic cancer incidence presented in the Publication 103 ICRP and in the UNSCEAR 2006, despite their external differences. Conclusion: Further work with the model requires the verification of parameter values by comparison with the epidemiological data, primarily with data on the incidence of solid cancers in the Japanese cohort. However, since some of the assumptions of the model, including the new one, are not purely radiobiological, it would require analysis of a wider range of biological and cancer patterns.
Subjects by Vocabulary

Microsoft Academic Graph classification: Statistics Cancer incidence Incidence (geometry) Solid cancer Mathematics Cohort Mathematical model Radiation Carcinogenesis Range (statistics) Consistency (statistics)

Subjects

mathematical models, quasi-biological model, radiation carcinogenesis, stem cells kinetics, pre-carcinogenic damage, solid cancer, morbidity, mortality, aging, Medical physics. Medical radiology. Nuclear medicine, R895-920, Radioactivity and radioactive substances, QC794.95-798, Radiology, Nuclear Medicine and imaging

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