publication . Other literature type . Article . 2017

ADDITION TO THE QUASI-BIOLOGICAL MODEL OF RADIOGENIC CANCER MORBIDITY

A. Т. Gubin; V. A. Sakovich;
Open Access
  • Published: 01 Jan 2017
  • Publisher: SPRI of Radiation Hygiene Prof. PV Ramzaev
Abstract
Object: The purpose was to refine the quasi-biological model of the incidence of radiogenic solid cancer (published by the authors earlier in the journal “Radiation hygiene”) to ensure better consistency with the Japanese cohort data and with the ICRP model in part of the description of the effect of age at exposure. Results: Initial presuppositions of a mathematical model was supplemented by the assumption that stem cells, received the “pre-cancerous” defect of DNA, with a higher probability compared to the intact cells follow the path of reproduction but not of differentiation. Structure of the refined model and its properties did not change, but one parameter...
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free text keywords: mathematical models, quasi-biological model, radiation carcinogenesis, stem cells kinetics, pre-carcinogenic damage, solid cancer, morbidity, mortality, aging, Radiation Carcinogenesis, Cancer incidence, Cohort, Cancer, medicine.disease, medicine, Oncology, medicine.medical_specialty, Solid cancer, business.industry, business, Internal medicine, lcsh:Medical physics. Medical radiology. Nuclear medicine, lcsh:R895-920, lcsh:Radioactivity and radioactive substances, lcsh:QC794.95-798
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