publication . Article . 2008

Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia

Ibrahim Turkoz; Cynthia A. Bossie; Bryan Dirks; Carla M. Canuso;
Open Access English
  • Published: 01 Aug 2008 Journal: Neuropsychiatric Disease and Treatment, volume 4, issue 5, pages 949-958 (issn: 1176-6328, eissn: 1178-2021, Copyright policy)
  • Publisher: Dove Medical Press
Abstract
Ibrahim Turkoz, Cynthia A Bossie, Bryan Dirks, Carla M CanusoOrtho-McNeil Janssen Scientific Affairs, LLC, Titusville, NJ, USAAbstract: Direct and indirect effects of the new psychotropic paliperidone extended-release (paliperidone ER) tablets on negative symptom improvement in schizophrenia were investigated using path analysis. A post hoc analysis of pooled data from three 6-week, double-blind, placebo-controlled studies of paliperidone ER in patients experiencing acute exacerbation was conducted. Regression analysis explored relationships between baseline/study characteristics and negative symptoms. Change in Positive and Negative Syndrome Scale (PANSS) negat...
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Subjects
free text keywords: Expert Opinion, antipsychotic, paliperidone ER, path analysis, psychotropic, schizophrenia, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:RC321-571, lcsh:Neurology. Diseases of the nervous system, lcsh:RC346-429, Post-hoc analysis, Antipsychotic, medicine.medical_treatment, medicine, Anxiety, medicine.symptom, Schizophrenia, medicine.disease, Internal medicine, medicine.medical_specialty, Paliperidone, medicine.drug, business.industry, business, Positive and Negative Syndrome Scale, Exacerbation, Psychiatry, Movement disorders
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