This study investigated the relationship between Home Environment and Students’ Academic Performance in Biology in Senior Secondary School in Calabar Municipality Local Government Area of Cross River State. Four hypotheses were formulated with the following variables parental financial status and academic performance of students, parental marital status and student academic performance, parent educational background and student academic performance, and parent attitude towards their children education and students’ academic performance. Literature was reviewed based on the variables, ex-post facto research design was adopted for the study, a questionnaire was constructed and administered to five secondary schools in Calabar Municipality consisting of fourty (40) students each and a total of two hundred (200) students were randomly selected for the purpose of collecting data to test the hypotheses. Pearson Product Moment Correlation Statistics was used to test these hypotheses. The hypotheses were tested at 198 degree of freedom and at 0.05 level of significant. The following findings emerged. There was no significant relationship between parent financial status and student academic performance, there was a significant relationship between parent marital status and student academic performance. There was significant relationship between parent educational background and student academic performance, there is significant relationship between parent attitude towards their children education and students academic performance in Biology in secondary schools in Calabar Municipality. Based on these, it was recommended among others that parents should learn to live together and bring up their children with love.