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Transplacental transmission of SARS-CoV-2 infection.

Name: Transplacental transmission of SARS-CoV-2 infection.
Keywords: Betacoronavirus, COVID-19, Coronavirus Infections, Female, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Male, Maternal-Fetal Exchange, Mothers

descriptionPublicationkeyboard_double_arrow_right Other literature type , Article , Preprint 14 Jul 2020Nature communications, volume 11, issue 1 (issn: 2041-1723,

Alexandre J. Vivanti; Christelle Vauloup-Fellous; Sophie Prevot; Veronique Zupan; Cecile Suffee; Jeremy Do Cao; Alexandra Benachi; +1 Authors

doi: 10.21203/rs.3.rs-28884/v1 , 10.1038/s41467-020-17436-6

pmid: 32665677

pmc: PMC7360599

Transplacental transmission of SARS-CoV-2 infection.

- Summary
- Subjects
- References
  (25)
- Metrics

Abstract

SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients.

Congenital infection of SARS-CoV-2 has been described, but the transmission routes remain unclear. Here, the authors report evidence of transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise.

Country

France

Related Organizations

Université Paris Diderot
France
Inserm
France

Subjects by Vocabulary

Medical Subject Headings: fungi virus diseases viruses skin and connective tissue diseases body regions respiratory tract diseases

Library of Congress Subject Headings: lcsh:Science lcsh:Q

Microsoft Academic Graph classification: Immunology Transplacental transmission Medicine business.industry business Placenta medicine.anatomical_structure Pregnancy medicine.disease Pneumonia (non-human) Fetus Viral load Viremia Transmission (medicine)

Keywords

Betacoronavirus, COVID-19, Coronavirus Infections, Female, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Male, Maternal-Fetal Exchange, Mothers, Pandemics, Placenta, Pneumonia, Viral, Pregnancy, Pregnancy Complications, Infectious, SARS-CoV-2, Vasculitis, Central Nervous System, Viral Load, Viremia, Young Adult, Article, Infectious diseases, Paediatrics, General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Science, Q, Multidisciplinary, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases

25 references, page 1 of 3

1. Zeng, H. et al. Antibodies in infants born to mothers with COVID-19 pneumonia. JAMA 323, 1848-1849 (2020).

2. Dong, L. et al. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA 323, 1846-1848 (2020).

3. Zeng, L. et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Pediatr. https://doi. org/10.1001/jamapediatrics.2020.0878 (2020).

4. Zhu, H. et al. Clinical analysis of 10 neonates born to mothers with 2019- nCoV pneumonia. Transl. Pediatr. 9, 51-60 (2020).

5. Yu, N. et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect. Dis. 20, 559-564 (2020).

6. Alzamora, M. C. et al. Severe COVID-19 during Pregnancy and possible vertical transmission. Am. J. Perinatol. https://doi.org/10.1055/s-0040-1710050 (2020). [OpenAIRE]

7. American College of Obstetricians and Gynecologists. Practice bulletin no. 106: intrapartum fetal heart rate monitoring: nomenclature, interpretation, and general management principles. Obstet. Gynecol. 114, 192-202 (2009).

8. Perlman, J. M. et al. Part 7: neonatal resuscitation: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (Reprint). Pediatrics 136, S120-S166 (2015).

9. Singh, Y. et al. International evidence-based guidelines on point of care ultrasound (POCUS) for critically ill neonates and children issued by the POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC). Crit. Care 24, 65 (2020).

10. De Luca, D. et al. Role of distinct phospholipases A2 and their modulators in meconium aspiration syndrome in human neonates. Intensiv. Care Med. 37, 1158-1165 (2011).

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Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	643
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Exceptional
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Substantial
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Exceptional

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	643
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Exceptional
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Substantial
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Exceptional