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ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2019Publisher:AME Publishing CompanyJournal:Annals of Translational Medicine, volume 7, pages 686-686 (issn: 2305-5839, eissn: 2305-5847,

Authors: Wen Gao; Yue Zhang; Jing Xu; Huizhu Qian;

doi: 10.21037/atm.2019.11.06

pmid: 31930087

pmc: PMC6944604

ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications

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Abstract

Adenosine deaminases acting on RNA (ADARs) catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNA, which can change the codons after transcription. Abnormal ADAR editing is present in a variety of cancers. However, the study of the biological effects of ADARs in cancer is not very deep. Here, we review current important ADAR-mediated editing events, related carcinogenic mechanisms and applications in clinical medicine. Further exploration in ADARs can provide a new direction for cancer treatment.

Related Organizations

Jiangsu Province Hospital
China (People's Republic of)
Nanjing Medical University
China (People's Republic of)

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	18
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%