publication . Article . 2020

The Possibilities of Single-Pill Combinations of Antihypertensive Drugs in Cerebroprotection: Focus on the Combination of Amlodipine with Ramipril

Aleksei I. Kochetkov; S. V. Batyukina; O. D. Ostroumova; M. Yu. Nazranova; V. N. Butorov;
Open Access
  • Published: 04 Jul 2020 Journal: Rational Pharmacotherapy in Cardiology, volume 16, pages 487-497 (issn: 1819-6446, eissn: 2225-3653, Copyright policy)
  • Publisher: Stolichnaya Izdatelskaya Kompaniyaizdat
Abstract
Stroke remains one of the leading causes of death and disability both worldwide and in Russia. Acute cerebrovascular events have many risk factors, among them the most important is arterial hypertension (AH), which predisposes to the stroke development through the direct effect of increased hydrostatic blood pressure on the brain vascular system, followed by arterial remodeling and an increase in their stiffness. In addition, excessive blood pressure variability, activation of the tissue renin-angiotensin-aldosterone system, as well as target-organ damage - primarily the heart in the form of left ventricular hypertrophy, kidneys in the form of microalbuminuria a...
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Subjects
free text keywords: stroke, arterial hypertension, brain, target organ damage, antihypertensive therapy, single-pill combination, ramipril, amlodipine, Therapeutics. Pharmacology, RM1-950, Diseases of the circulatory (Cardiovascular) system, RC666-701, Ramipril, medicine.drug, medicine, Amlodipine, Calcium channel blocker, medicine.drug_class, Hyperuricemia, medicine.disease, Angiotensin-converting enzyme, biology.protein, biology, Blood pressure, Left ventricular hypertrophy, Internal medicine, medicine.medical_specialty, Cardiology, business.industry, business, Stroke
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