publication . Article . 2020

Drug Interactions and Side Effects of Co-Administration of Chloroquine/Hydroxychloroquine and Azithromycin: on the Issue of Rational Pharmacotherapy of Patients with COVID-19 with Antimalarial Drugs

O. V. Gaisenok;
Open Access
  • Published: 04 Jul 2020 Journal: Rational Pharmacotherapy in Cardiology, volume 16, pages 481-486 (issn: 1819-6446, eissn: 2225-3653, Copyright policy)
  • Publisher: Stolichnaya Izdatelskaya Kompaniyaizdat
Abstract
This review analyzes existing approaches to the treatment of COVID-19 patients with antimalarial drugs from the standpoint of rational pharmacotherapy. Particular attention is paid to drug interactions and side effects of co-administration of chloroquine/hydroxychloroquine and azithromycin, considering the problem of cardiotoxicity and the high likelihood of cardiovascular disease in middle-aged and elderly people with COVID-19. The article discusses the prospects of using another representative from the group of antimalarial drugs - mefloquine in the treatment of COVID-19. Special attention is paid to the “proarrhythmogenic” side effects of azithromycin therapy...
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Subjects
free text keywords: covid-19, chloroquine, hydroxychloroquine, azithromycin, drug interactions, side effects, Therapeutics. Pharmacology, RM1-950, Diseases of the circulatory (Cardiovascular) system, RC666-701, Mefloquine, medicine.drug, medicine, Chloroquine, Disease, Intensive care medicine, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Hydroxychloroquine, Azithromycin, business.industry, business, Drug, media_common.quotation_subject, media_common, Cardiotoxicity
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