publication . Article . Other literature type . 2017

Statins and their interaction with model cell membranes according to the data of nuclear magnetic resonance spectroscopy

I. A. Latfullin; L. F. Galiullina; G. S. Musabirova; Oksana V. Aganova; Z. F. Kim; Albert V. Aganov; Vladimir V. Klochkov;
Open Access
  • Published: 01 May 2017
Abstract
Aim. To study the location of pravastatin, simvastatin, fluvastatin and cerivastatin in molecular complexes with model cell membranes based on dodecylphosphocholine, and also to calculate the average interatomic distances between the atoms of statins and micelles. Material and methods. Nuclear magnetic resonance (NMR) spectroscopy was chosen as a method of study. NMR spectroscopy of the Overhauser nuclear effect (NOESY) is one of the most effective methods in the study of intermolecular interactions, in particular, in studies of drugs. Information on the spatial structure of the molecular complex, as well as on the fragments of molecules responsible for the effe...
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free text keywords: Dodecylphosphocholine, Micelles, Molecular complex, Nuclear magnetic resonance, Statins, Spectroscopy, Chemical structure, Membrane, Crystallography, Nuclear magnetic resonance spectroscopy, Two-dimensional nuclear magnetic resonance spectroscopy, Intermolecular force, Micelle, Molecule, Medicine, business.industry, business, lcsh:Therapeutics. Pharmacology, lcsh:RM1-950, lcsh:Diseases of the circulatory (Cardiovascular) system, lcsh:RC666-701
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