publication . Preprint . Other literature type . Article . 2020

Self-adaptive Biosystems Through Tunable Genetic Parts and Circuits

Bartoli, Vittorio; di Bernardo, Mario; Gorochowski, Thomas E.;
Open Access English
  • Published: 06 Oct 2020
  • Publisher: Preprints
Biological systems often need to operate in complex environments where conditions can rapidly change. This is possible due to their inherent ability to sense changes and adapt their behavior in response. Here, we detail recent advances in the creation of synthetic genetic parts and circuits whose behaviors can be dynamically tuned through a variety of intra- and extra-cellular signals. We show how this capability lays the foundation for implementing control engineering schemes in living cells and allows for the creation of biological systems that are able to self-adapt, ensuring their functionality is maintained in the face of varying environmental and physiolog...
Persistent Identifiers
free text keywords: biochemistry, biotechnology
Funded by
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
  • Funder: European Commission (EC)
  • Project Code: 766840
  • Funding stream: H2020 | RIA
Validated by funder
UKRI| EPSRC and BBSRC Centre for Doctoral Training in Synthetic Biology
  • Funder: UK Research and Innovation (UKRI)
  • Project Code: EP/L016494/1
  • Funding stream: EPSRC
UKRI| BrisSynBio: Bristol Centre for Synthetic Biology
  • Funder: UK Research and Innovation (UKRI)
  • Project Code: BB/L01386X/1
  • Funding stream: BBSRC
FET H2020FET OPEN: FET-Open research and innovation actions
FET H2020FET OPEN: Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
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