publication . Article . 2017

Association of СОМТ gene polymorphisms with Parkinson’s disease

Open Access English
  • Published: 01 Oct 2017 Journal: Bûlleten' Sibirskoj Mediciny, volume 16, issue 3, pages 70-78 (issn: 1682-0363, eissn: 1819-3684, Copyright policy)
  • Publisher: Siberian State Medical University (Tomsk)
Parkinson’s disease (PD) is one of the most serious and widespread neurodegenerative disorders. Genetic susceptibility plays a significant role in the development of PD. The aim of our study was to investigate associations between single nucleotide polymorphisms (SNPs) of the COMT gene coding dopamine catabolism enzyme and Parkinson’s disease. Materials and methods. In this study seven SNPs (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) of COMT were genotyped. 232 patients with PD and 127 healthy individuals in the Siberian region of Russia were examined. Venous blood samples were drawn as a marker of PD. Statistical differences in the prevalence...
free text keywords: parkinson’s disease, single nucleotide polymorphisms, comt gene, Parkinson's disease, CATECHOL-O-METHYLTRANSFERASE, SUSCEPTIBILITY, RISK, EPIDEMIOLOGY, METAANALYSIS, POPULATION, SCALE, DRD2, lcsh:Medicine, lcsh:R, Allele, rs4680, Genetic predisposition, Genetics, Genotype, Polymorphism (computer science), medicine.disease, medicine, Single-nucleotide polymorphism, Disease, business.industry, business
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