publication . Article . 2016

THE ROLE OF PROTEIN OXIDATIVE MODIFICATION IN REDOX-REGULATION OF CASPASE-3 ACTIVITY IN BLOOD LYMPHOCYTES DURING OXIDATIVE STRESS IN VITRO

O. L. Nosareva; Ye. A. Stepovaya; N. V. Ryazantseva; Ye. V. Shakhristova; O. N. Vesnina; V. V. Novitsky;
Open Access
  • Published: 01 Feb 2016 Journal: Bulletin of Siberian Medicine, volume 14, pages 61-67 (issn: 1682-0363, eissn: 1819-3684, Copyright policy)
  • Publisher: Siberian State Medical University
Abstract
<jats:p>The formation of oxidative stress lies at the heart of many frequent and socially-important diseases. Blood lymphocytes are the cells which provide immunological control of our organism. As a result of their function implementation blood lymphocytes contact with different endogenic and exogenic factors, which can lead to active oxygen species production activation, macromolecules oxidative modification and to cell survival alteration. At the present time it is essential to expand and deepen the fundamental knowledge of blood lymphocytes apoptosis regulation peculiarities. The research objective was to establish the interaction among alterations of glutat...
Subjects
free text keywords: blood lymphocytes, oxidative stress, glutathione system, cell redox-status, oxidative protein modification, caspase-3, lcsh:Medicine, lcsh:R, Biochemistry, Apoptosis, Programmed cell death, Glutathione, chemistry.chemical_compound, chemistry, Glutathione reductase, medicine.disease_cause, medicine, Caspase 3, Protein glutathionylation, Oxidative phosphorylation
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