publication . Article . 2016


Open Access Russian
  • Published: 01 Feb 2016 Journal: Alʹmanah Kliničeskoj Mediciny, issue 41, pages 79-88 (issn: 2072-0505, eissn: 2587-9294, Copyright policy)
  • Publisher: MONIKI
The review describes the current views on urothelial carcinoma carcinogenesis. Based on the up-todate genetic studies, molecular pathways determining the development of superficial and invasive bladder cancers are considered. It was demonstrated that the development of noninvasive bladder tumors occurred predominantly through oncogenes activation, while the genesis of invasive cancer is based on inactivation of tumor suppressor genes. Principal mechanisms of multiple and recurrent bladder tumors development are discussed including its monoclonal and oligoclonal models. One of the most promising nowadays approaches is the determination of new generation markers, ...
Persistent Identifiers
free text keywords: superficial and invasive bladder cancer, mutations, gene, fgfr3, тр53, monoclonal and oligoclonal bladder tumors, lcsh:Medicine, lcsh:R, Malignant transformation, Monoclonal, Suppressor, law.invention, law, Cell, medicine.anatomical_structure, medicine, Pathology, medicine.medical_specialty, Urothelial carcinoma, Carcinogenesis, medicine.disease_cause, business.industry, business, Invasive carcinoma
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