This article examines the U.S. foreign policy towards Colombia with respect to drug trafficking. The analysis concentrates not only on the War on Drugs in Colombia but also on the interests of the U.S. in this country and in the region as a whole. The position of Colombia in the War on Drugs and the response of Washington to this problem highlight the foreign policy of the U.S. towards other countries in the region regarding drug trafficking and organized crime. This work analyzes cooperation between the U.S. and Colombia regarding the drug war. We conclude the article by assessing the cooperation between the United States and Colombia, taking into account the outcomes but also the kind of predominant cooperation.