publication . Article . Other literature type . 2015

News in the studies of multidrug resistance of breast cancer cells

Open Access Russian
  • Published: 01 Jun 2015 Journal: Uspehi Molekulârnoj Onkologii, volume 2, issue 1, pages 39-51 (issn: 2413-3787, Copyright policy)
  • Publisher: ABV-press
Abstract
Breast cancer (BC) is the most common cancer among women in Russia. One of the main treatment methods of BC is systemic chemotherapy. Multidrug resistance of tumor cells (MDR) is the important hindrance on the way to successful chemotherapy. The new data concerning molecular mechanisms of MDR will be presented in this review. The recent data concerning some new biological prognostic markers will be also discussed. There are data showing that transporters of ABC family (ABC transporters) influence tumor progression not only by MDR induction but also by the influence on the traits of malignancy in tumor cells. The results of the studies of ABC transporters, partic...
Subjects
free text keywords: breast cancer, tumor progression, multidrug resistance, biological tumor markers, transporters of abc family, tumor stem cells, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, ATP-binding cassette transporter, Protein kinase B, Pharmacology, Protein phosphatase 2, PTEN, biology.protein, biology, Cancer, medicine.disease, medicine, Multiple drug resistance, Cancer research, Fascin
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