publication . Article . 2017

CYCLOPHILIN A: STRUCTURE AND FUNCTIONS

Open Access
  • Published: 01 Dec 2017 Journal: Advances in molecular oncology, volume 4, pages 17-23 (issn: 2313-805X, eissn: 2413-3787, Copyright policy)
  • Publisher: Publishing House ABV Press
Abstract
Cyclophilins belong to a large family of ancient conservative proteins with peptidyl-prolyl-cis-trans isomerase activity. The main member of this family – cyclophilin A – was discovered as an intracellular ligand for cyclosporine A. Further investigations revealed a wide range of functions of cyclophilin A. Cyclophilin A is involved in T-cell signaling, it takes part in folding, assembly and intracellular transport of proteins, as well as acts as an antioxidant. Different cell types secrete cyclophilin A under infection or oxidative stress. Cyclophilin A is one of the main factors involved in inflammation and pathogenesis of autoimmune, cardiovascular and other ...
Persistent Identifiers
Subjects
Medical Subject Headings: polycyclic compoundsenzymes and coenzymes (carbohydrates)cardiovascular system
free text keywords: peptidyl-prolyl isomerase, cd147, chemoattractant, cyclosporine a, inflammation, Intracellular, Isomerase activity, Cyclophilin A, Secretion, Biology, Cell biology, Tumor progression, Cyclophilin, Pathogenesis, Chemotaxis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282
Any information missing or wrong?Report an Issue