publication . Article . 2017

Exosomes and development of cancer cell resistance to metformin: pilot study

Open Access Russian
  • Published: 01 Oct 2017 Journal: Uspehi Molekulârnoj Onkologii, volume 4, issue 3, pages 92-98 (issn: 2413-3787, Copyright policy)
  • Publisher: ABV-press
Abstract
Objective : to study the role of the intercellular interactions in the progression of the cancer cells resistance to metformin, a biguanide antidiabetic drug exhibited the marked anti-tumor activity. Results . Earlier we have demonstrated the effect of horizontal transferring of hormonal resistance of breast cancer cells  from cell to cell, and showed the key role of exosomes on the transferring of the resistance. Here we have shown the effect of the horizontal transferring of metformin resistance in breast cancer cells – similar to the progression of hormonal resistance. We found that horizontal transferring of the metformin resistance is mediated via exosomes ...
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Subjects
free text keywords: breast cancer, resistance, metformin, exosomes, intercellular interactions, proteome, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Intracellular, Cancer research, Cell, medicine.anatomical_structure, medicine, Cancer cell, medicine.drug, business.industry, business, medicine.disease, Microvesicles, Biguanide, medicine.drug_class, Apoptosis
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