publication . Article . 2017

Secreted protein YB-1 and its prognostic significance

A. A. Stavrovskaya; N. I. Moiseeva; Gelena P. Guens; E. Yu . Rybalkina;
Open Access Russian
  • Published: 01 Oct 2017 Journal: Uspehi Molekulârnoj Onkologii, volume 4, issue 3, pages 50-56 (issn: 2413-3787, Copyright policy)
  • Publisher: ABV-press
Abstract
The multifunctional protein YB-1 in prokaryotes and eukaryotes participates in various processes, among others performing the functions  of a regulator of transcription and translation of many genes. Intracellular localization and expression of YB-1 is an acknowledged prognostic marker for certain malignant tumors. However, it has recently become clear that YB-1 can be released from cells and present in body fluids, including inside vesicles. The review collected data on the secretion YB-1 (sYB-1) content in blood serum from patients with inflammatory diseases and various tumors. There is analyzed the influence of sYB-1 on normal and tumor cells. Data are presen...
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Subjects
free text keywords: secreted yb-1, yb-1/p18, biological tumor marker, sasp, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Chemistry, Cancer research
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