publication . Article . 2017

THE IMPACT OF H YPOTHALAMIC-PITUITARY-ADRENAL SYSTEM HORMONES ON EPILEPTOGENESIS

Open Access Russian
  • Published: 01 Apr 2017 Journal: Russkij Žurnal Detskoj Nevrologii, volume 12, issue 1, pages 47-55 (issn: 2073-8803, eissn: 2412-9178, Copyright policy)
  • Publisher: ABV-press
Abstract
Some issues concerning the impact of hypothalamic-pituitary-adrenal system (HPAS) hormones on epileptogenesis are discussed in the article. It was found, that they have a direct and indirect impact. Direct effect implies the reduction of excitation level in the brain cells by affecting membrane channels and receptors involved in the regulation of certain neurotransmitters synthesis. Indirect effect is realized through positive influence on the brain neurons maturation process, leveling the stimulation of excitation processes mediated by biologically active substances, ions and other agents. Adrenocorticotropic hormone and glucocorticosteroids are the main hormon...
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free text keywords: epilepsy, hormones, hypothalamic-pituitary-adrenal system, antiepileptic therapy, lcsh:Neurology. Diseases of the nervous system, lcsh:RC346-429, Adrenocorticotropic hormone, Receptor, Epileptogenesis, Stimulation, Secretion, Neuroscience, medicine.disease, medicine, Hormone, Indirect effect, Chemistry
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