publication . Article . 2021

The role of bone marrow microenvironment in the progression of multiple myeloma from monoclonal gammopathy of undetermined significance

A. S. Khudovekova; Ya. A. Rudenko; A. E. Dorosevich;
Open Access
  • Published: 10 Sep 2021 Journal: Oncohematology, volume 16, pages 26-32 (issn: 1818-8346, eissn: 2413-4023, Copyright policy)
  • Publisher: Publishing House ABV Press
Abstract
Multiple myeloma is a tumor of plasma cells, one of the most common malignant blood diseases. It is preceded by a stage called monoclonal gammopathy of undetermined significance, from which true multiple myeloma develops in only a small percentage of cases. It was assumed that this process is associated with the accumulation of genetic mutations, but in recent years there is increasing evidence that the bone marrow microenvironment plays a key role in progression and that it can become a target for therapy that prevents the myeloma development. The review considers the role of mesenchymal stem cells, immune system cells, endotheliocytes, fibroblasts, adipocytes,...
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free text keywords: Oncology, Hematology
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