publication . Article . 2021

Pharmacokinetics of low molecular weight heparins in thrombosis, complicate the treatment of children with cancer

V. V. Dmitriev; N. V. Lipay; N. V. Migal; I. V. Begun; E. V. Dmitriev;
Open Access Russian
  • Published: 14 Apr 2021 Journal: Onkogematologiâ, volume 16, issue 1, pages 73-82 (issn: 1818-8346, Copyright policy)
  • Publisher: ABV-press
Abstract
Objective: to evaluate the pharmacokinetics of nadroparin and dalteparin in thrombosis complicating the treatment of children with malignant neoplasms.Materials and methods. The results of 52 pharmacokinetic studies performed in 34 patients with malignant neoplasms, whose treatment was complicated by venous thrombosis, were analyzed. The age of the patients is from 7 to 18 years, he median is 14.5 years. Depending on the value of daily dose and type of heparin administered, the results of pharmacokinetic studies were divided into 6 groups. Dalteparin sodium: during period of chemotherapy induced thrombocytopenia, subcutaneous injection at a dose of 51.0 (40.0-72...
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free text keywords: venous thrombosis, malignant neoplasms, children, adolescents, anticoagulant therapy, low molecular weight heparin, Diseases of the blood and blood-forming organs, RC633-647.5
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