publication . Article . 2021

Prospects for predicting the course of nodular sclerosis Hodgkin lymphoma by morphometric analysis of CD163-positive macrophages

M. S. Minaev; E. A. Perfilova; D. A. Diakonov; A. A. Kuzmin; N. B. Pavlova; D. M. Konovalov; I. V. Paramonov;
Open Access
  • Published: 14 Apr 2021 Journal: Oncohematology, volume 16, pages 47-53 (issn: 1818-8346, eissn: 2413-4023, Copyright policy)
  • Publisher: Publishing House ABV Press
Abstract
Background. In present days, much attention is paid to the study of the interrelation between the macrophage/hystiocytic microenvironment and the tumor substrate in lymphoproliferative disorders.Objective. The article is devoted to the morphometric and morphological assessment of CD163-positive macrophages in nodular sclerosis Hodgkin lymphoma.Materials and methods. Formalin fixed, paraffin-embedded (FFPE) lymph node samples of 45 patients were used for the study. To identify and visualize CD163-positive cells in the test material, an immunohistochemical staining method was used.Results. The study shows that the morphometric and morphological analysis of CD163-p...
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Subjects
Medical Subject Headings: genetic structurespsychological phenomena and processes
free text keywords: hodgkin lymphoma, marker, cd163, prognosis, Diseases of the blood and blood-forming organs, RC633-647.5
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