publication . Article . 2019

Breakthrough invasive candidiasis in pediatric patient with Ewing’s sarcoma: dinical case report and literature review

Dinikina, Yu. V.; Shadrivova, O. V.; Belogurova, M. B.; Ignatyeva, S. M.; Bogomolova, T. S.; Klimko, N. N.;
Open Access Russian
  • Published: 22 Dec 2019 Journal: Onkogematologiâ, volume 14, issue 4, pages 59-66 (issn: 1818-8346, Copyright policy)
  • Publisher: ABV-press
Abstract
We presented clinical case of invasive candidiasis in 13 years old girl with Ewing's sarcoma during intensive treatment with combined chemotherapy according EWING 2008 protocol. The most significant risk factors were recurrent chemotherapy induced neutropenia gr IV, multifocal Candida colonization, prolonged central venous catheter use, combined antibiotic therapy in the previous >10 days, parenteral nutrition. In spite of provided prophylaxis and antifungal therapy patient died because of progression of invasive candidiasis. We analyzed literature data on frequency of invasive candidiasis in children with Ewing's sarcoma and cases of breakthrough candidiasis...
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free text keywords: children, oncology, ewing's sarcoma, chemotherapy, candidiasis, invasive mycosis, echinocandins, antifungal therapy, lcsh:Diseases of the blood and blood-forming organs, lcsh:RC633-647.5, Sarcoma, medicine.disease, medicine, Gastroenterology, medicine.medical_specialty, Neutropenia, Chemotherapy, medicine.medical_treatment, Ewing's sarcoma, Parenteral nutrition, Combination chemotherapy, Central venous catheter, Chemotherapy induced, Internal medicine, business.industry, business
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