publication . Article . 2019

Bone marrow adipocytes and multiple myeloma

A. A. Фильченков;
Open Access Russian
  • Published: 10 Apr 2019 Journal: Onkogematologiâ, volume 14, issue 1, pages 60-75 (issn: 1818-8346, Copyright policy)
  • Publisher: ABV-press
Abstract
Multiple myeloma originating from clonal proliferation of plasma cells in the bone marrow is one of the most prevalent hematological malignancies worldwide. The pathogenetic mechanisms of multiple myeloma are far from being elucidated. Nevertheless, it is known that the adipocytes as the prevalent cellular component of bone marrow microenvironment contribute significantly to multiple myeloma growth and progression. The review discloses the recent data on the interactions between bone marrow adipocytes and myeloma cells, hematopoietic stemcells, hematopoietic progenitor cells, mesenchimal stem cells, osteoblasts, osteoclasts, endothelial cells, and cells of immun...
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free text keywords: plasma cell neoplasms, adipose tissue, proliferation, apoptosis, differentiation, myeloma cells, lymphocytes, nkt cells, macrophages, myeloid-derived suppressor cells, lcsh:Diseases of the blood and blood-forming organs, lcsh:RC633-647.5, Multiple myeloma, medicine.disease, medicine, Myeloid-derived Suppressor Cell, Biology, Haematopoiesis, Plasma cell neoplasm, Natural killer T cell, Bone marrow, medicine.anatomical_structure, Cancer research, Stem cell, Angiogenesis
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