publication . Article . 2019

Role of KIR typing in donor selection prior to allogeneic hematopoietic stem cell transplantation: literature review

Zakharova, V. V.;
Open Access Russian
  • Published: 03 Jan 2019 Journal: Onkogematologiâ, volume 13, issue 4, pages 67-74 (issn: 1818-8346, Copyright policy)
  • Publisher: ABV-press
Abstract
Natural killer (NK) cells are the first population to recover after allogeneic hematopoietic stem cell transplantation. Since the report in 2002 by L. Rugerri et al. showing the effectiveness of NK cell alloreactivity in haploidentical stem cell transplantation, a lot of conflicting studies have appeared about the role of NK alloreactivity in haploidentical and matched unrelated donor transplantations. Current studies demonstrate that the beneficial effects of donor NK alloreactivity are dependent on the transplant protocol – conditioning regimen, graft processing procedure and graft-versus-host disease.
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Medical Subject Headings: surgical procedures, operative
free text keywords: killer cell immunoglobulin-like receptors, kir typing, hla typing, hematopoietic stem cell transplantation, lcsh:Diseases of the blood and blood-forming organs, lcsh:RC633-647.5, Beneficial effects, Human leukocyte antigen, Conditioning regimen, Transplantation, Hematopoietic stem cell transplantation, medicine.medical_treatment, medicine, Immunology, Population, education.field_of_study, education, Stem cell, Cell, medicine.anatomical_structure, business.industry, business
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