publication . Article . 2018

Modern concepts of the mycosis fungoides pathogenesis

Vorontsova, A. A.; Karamova, A. E.; Znamenskaya, L. F.;
Open Access Russian
  • Published: 27 Oct 2018 Journal: Onkogematologiâ, volume 13, issue 3, pages 39-46 (issn: 1818-8346, Copyright policy)
  • Publisher: ABV-press
Abstract
Mycosis fungoides – the most common form of cutaneous T-cell lymphoma. The pathogenesis of this disease is complex and remains unclear. The article contains a review of the literature devoted to the main mechanisms of T-lymphocytes malignant proliferation, known to date. Data on dysregulation of immune, genetic and epigenetic mechanisms, as well as the role of microenvironment cells in the proliferation of T lymphocytes, are given. Immunophenotypic characteristics and cellular composition of the infiltrate in patients with mycosis fungoides, are described depending on the stage of the disease. Prospective directions in studying molecular-biological predictors of...
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free text keywords: cutaneous t-cell lymphoma, mycosis fungoides, mechanisms of development, pathogenesis, cytokines, interleukin, t-lymphocytes, signaling proteins, micro-rna, lcsh:Diseases of the blood and blood-forming organs, lcsh:RC633-647.5, Cutaneous T-cell lymphoma, medicine.disease, medicine, Immune system, Interleukin, Epigenetics, Mycosis fungoides, Cancer research, business.industry, business, microRNA, Lymphoma, Pathogenesis
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