publication . Part of book or chapter of book . Article . 2006

Myelodysplastic/Myeloproliferative Diseases

Wojciech Gorczyca; James Weisberger; Foxwell Emmons;
Open Access
  • Published: 12 Jan 2006
  • Publisher: SAGE Publications, Inc.
Abstract
The myelodysplastic/myeloproliferative disorders (MDS/MPD) are a group of hematologic disorders distinguished by clonal expansion of abnormal hematopoietic stem cells that share clinicopathological features of both MDS and chronic myeloproliferative disorders (CMPD). They are characterized by hypercellular bone marrows with excessive terminal proliferation of one or more hematopoietic lineages as well as dysplastic changes. This combination of proliferation and dysplasia may lead to increased production of one or more lineages (cytosis) and decreased production of other lineages simultaneously. According to the WHO classification, these disorders are divided int...
Subjects
Medical Subject Headings: hemic and lymphatic diseases
free text keywords: myeloproliferative diseases, chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, atypical chronic myeloid leukemia, refractory anemia with ringed sideroblasts, Diseases of the blood and blood-forming organs, RC633-647.5, Oncology, Hematology, Medicine, business.industry, business, Dermatology, medicine.medical_specialty, Myelodysplastic syndromes, medicine.disease, Myeloproliferative Disorders, Noonan syndrome, Cytogenetic Abnormality, Myelodysplastic–myeloproliferative diseases, Differential diagnosis, Thrombocytosis, Nosology, Immunology, Myeloid, medicine.anatomical_structure, Refractory anemia with ringed sideroblasts, Chronic myelomonocytic leukemia, Juvenile myelomonocytic leukemia, Atypical chronic myeloid leukemia, Bone marrow hypercellularity, Basophilia, Pathology
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