publication . Article . 2016

Methodological aspects of diagnostics and minimal residual disease monitoring in infant acute leukemias

Open Access
  • Published: 01 Mar 2016 Journal: Oncohematology, volume 11, pages 62-74 (issn: 1818-8346, eissn: 2413-4023, Copyright policy)
  • Publisher: Publishing House ABV Press
Abstract
Hereby we present methodological aspects and prognostic significance of minimal residual disease (MRD) monitoring in infant acute leukemias. Based on our own experience we made algorithm for detection of MRD in this group of patients. We conclude that general concordance between MRD detection by flow cytometry and real-time polymerase chain reaction (PCR) for fusion gene transcripts achieved 87.0 %. Concordance was significantly lower during induction in comparison to consolidation/intensification and relapse treatment (78.6; 90.4 and 93.4 %, correspondingly; p = 0.002). It was not dependent on presence of normal B-cell precursors. Concordance between MRD result...
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Subjects
Medical Subject Headings: hemic and lymphatic diseasesbody regions
free text keywords: 11q23/mll rearrangements, infant acute leukemias, Concordance, Hazard ratio, Minimal residual disease, Fusion gene, Relapse treatment, Confidence interval, Pathology, medicine.medical_specialty, medicine, Bone marrow, medicine.anatomical_structure, Gastroenterology, Peripheral blood, Internal medicine, business.industry, business, lcsh:Diseases of the blood and blood-forming organs, lcsh:RC633-647.5
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