publication . Article . 2015

Cell-binding microarray application in diagnosis of hairy cell leukemia

Open Access Russian
  • Published: 01 Jun 2015 Journal: Onkogematologiâ, volume 10, issue 1, pages 37-45 (issn: 1818-8346, Copyright policy)
  • Publisher: ABV-press
Abstract
<p>We describe an application of a cell-binding microarray – to parallel study of morphology, tartrate-resistant acid phosphatase activity and detection of surface markers on peripheral blood lymphocytes of 90  atients with suspected hairy cell leukemia (HCL). We have formulated the microarray-based diagnostic criteria for hairy cell leukemia, hairy cell leukemia variant (HCLv) and splenic marginal zone lymphoma (SMZL). According to these criteria we have suggested the presence of HCL for 55 patients, HCLv – for 7 patients and SMZL – for 10 patients from the studied cohort. These diagnoses were confirmed by standard diagnostic methods in all cases. These results...
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free text keywords: anti-CD antibody microarray, hairy cell leukemia, hairy cell leukemia variant, splenic marginal zone lymphoma, CD11c, CD25, CD103, CD123, lcsh:Diseases of the blood and blood-forming organs, lcsh:RC633-647.5, Leukopenia, medicine.symptom, medicine, medicine.disease, business.industry, business, Microarray, Hairy Cell, Pathology, medicine.medical_specialty, Interleukin-3 receptor
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