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Immuno-analytical characteristics of PSA and derived biomarkers (total PSA, free PSA, p2PSA)

Authors: Cédric, Desbène; Mathieu, Boissan; Sylvain, Loric; Pierre-Jean, Lamy; Laurence, Piéroni;

Immuno-analytical characteristics of PSA and derived biomarkers (total PSA, free PSA, p2PSA)

Abstract

Prostate-specific antigen (PSA) is the recommended tumor marker for individual screening and follow-up of prostate cancer. This paper reviews main structural and physiological data about prostate specific antigen isoforms: total PSA, free PSA, [-2]proPSA (also named p2PSA). It describes the pre-, per- and post-analytical conditions for these different parameters. It presents the interpretation of results and derived calculated indices (free/total PSA ratio, Prostate Health Index or PHI) for the management of prostate cancer (initial diagnosis and follow-up).

Keywords

Male, Biomarkers, Tumor, Humans, Protein Isoforms, Prostatic Neoplasms, Prostate-Specific Antigen, Protein Precursors

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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Cancer Research
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